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For embryonic stem (ES) cell culture, even though the mechanisms of Oct4 involving cell fate regulation have been widely investigated, the postnatal role is still unclear.
To investigate the postnatal role of LMO4 in retinal development and function, LMO4 was conditionally ablated in retinal progenitor cells using the Pax6 alpha-enhancer Cre/LMO4flox mice.
To study the postnatal role of Lhx8 in oocyte activation, we conditionally ablated Lhx8 in oocytes of primordial follicles (primordial oocytes).
Recent studies have found intriguing evidence that vasculogenesis might play a postnatal role in neovascularisation (Crosby et al, 2000; Shintani et al, 2001).
The deletion of SIRT6 in KO mice also results in shortened lifespan and significantly reduced body weight, suggesting an important developmental and postnatal role for this protein:protein interaction (Mostoslavsky et al., 2006).
A postnatal role for Siglec-H expression was suggested by the lack of amplification at early embryonic stages with increased expression after birth (Fig. 3B), as also found for ESTs in Unigene (data not shown).
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Little, however, is known about the postnatal roles of Cdc42 in dendritic spines under physiological conditions.
Knockdown of area-X FoxP2 expression during song development results in inaccurate and incomplete imitation of tutor songs, suggesting important postnatal roles in auditory-guided motor learning.
However, all these mutants are embryonic lethal and as such postnatal roles of ATMIN, in for example DNA damage and cancer (Loizou et al., 2011), have not been easily assessed.
Although these reports highlight the general importance of AS trans-regulatory factors in embryonic and postnatal development, their role in the response of the heart to pathological stimuli and their therapeutic potential has barely been explored.
However, whether the PcG/trxG system plays a role in postnatal heart is unclear, partly because the embryonic lethality of many PcG/trxG mutations precluded functional study of postnatal development.
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