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The genes were initially identified by in silico analysis and their transcript characteristics, region-specific expression, postnatal expression, and hormonal regulation, and characteristics of the expressed proteins were characterized in vitro.
Their low postnatal expression and their roles in tumourigenesis and tumour neoangiogenesis mark them as attractive targets for anticancer therapy (Perk et al, 2005).
Somewhat surprisingly, two of these three modules significantly overlapped (P < 0.0001) with M2, which shows decreasing postnatal expression, and genes in common between these modules were also enriched for synaptic transmission.
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Despite its ubiquitous expression and important functions, the postnatal expression profile and subcellular localization of sialin in the salivary gland remains elusive.
The present study provides information about the postnatal expression level and spatiotemporal expression pattern of mRNAs coding for adult and embryonic GADs in rat brain.
In sheep, a single-nucleotide (nt) substitution is associated with altered postnatal expression of GTL2 and DLK1, although their imprinting is not perturbed.
In the mouse brain, CrT has been observed as early as embryonic day 13 [19], [19] and postnatal expression is observed in the hippocampus, neocortex, and basal ganglia [18].
Transgene expression from the PrP promoter is extremely low during embryonic development, with high-level postnatal expression largely restricted to neurons and glia of the CNS [ 25].
While ROCK is ubiquitously expressed in many tissues and cells in the body, the postnatal expression of Gli2 is primarily restricted to the growth plate [45] and hair follicle [46], [47].
Like miR-1, miR-25 has also been reported to repress the postnatal expression of Hand2 in cultured cardiomyocytes and in mouse hearts in vivo.
Our data shows that homozygous or heterozygous loss of EphA3 does not alter the progression of murine adenocarcinomas that result from Kras mutation or loss of Trp53, and we detected negligible postnatal expression of EphA3 in adult wild-type lungs.
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