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The start of this posterior effect in the 300 500 ms epoch was suggested by an interaction by Congruence and AP Distribution, F 3,81) = 3.98, p < 0.05.
The analyses testing for a figure effect in Experiment 1 showed that in addition to the posterior effect reported previously, there was also a figure effect in the anterior subset (F 1,14) = 11.9, p = .004).004
That is, in the non-word condition, we fixed an early 120 220 ms time-window in order to estimate a possible early negativity effect and a later one at 700 850 ms to assess a late posterior effect.
The combined posterior effect size for c.IVS2 + 1G >A and p.R19X is 1.23 and 1.66 SD below the mean, respectively.
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These posterior effects, though, seem surprising given the distribution of dopamine projections which arise from ventral tegmental areas and spread primarily to the frontal cortex and much less to posterior regions [6], [7].
Moreover, the comparison between related and unrelated conditions showed stronger left posterior effects as well.
Further investigation of these early posterior effects in voluntary procedures might benefit from the use of designs that more precisely indicate the start of preparation.
This difference of latencies attenuates the amplitude of the posterior N1 effect but not the anterior effect and that may account for the variation of the figure effect across experiments.
The lack of a posterior P1 effect in Experiment 2 combined with the likelihood of comparable generators across experiments strengthens the idea that the P1 effect is specific to the processing of illusory contours.
We calculated the rate of leiomyosarcoma per 1000 cases using the posterior random effect mean and constructed 95%% credible intervals (CrIs) using the posterior 2.5 and 97.5 percentiles and on the probability scale by applying the logistic retransformation to the posterior mean of the random effect mean parameter.
The real figures of Experiment 2 nevertheless elicited a modulation in the frontal region that was not observed in Experiment 1, as if a global shift of amplitude pulled out the ERPs toward the negative polarity, therefore causing the cancellation of the posterior (positive) effect and the emergence of a negativity over the anterior region.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com