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The hoarders also showed less activation than the healthy subjects in the posterior cingulate, an area involved in spatial orientation, memory and emotion.
This finding has been backed up by a newly published neuroimaging study which found that elevating serotonin levels in the brain increases connectivity in one of its most important "hubs" – an area called the posterior cingulate cortex.
It found an inverse correlation between the thickness of the posterior cingulate cortex, which is a key hub of the default mode network, and the intensity and duration of ayahuasca use.
Posterior cingulate cortex.
PCC posterior cingulate cortex, mPFC medial prefrontal cortex.
Differential activity was also seen in the posterior cingulate cortex, the fusiform, and the parahippocampic gyri.
Finally, the posterior cingulate, medial PFC and ventral PPC showed a V-shaped pattern.
Interestingly, the visual and the posterior cingulate cortices show reduced BOLD signal during both imagery conditions.
Posterior cingulate cortex is identified as a hub in the networks that separate fixation from tasks.
We also observe a network running from the left to right parietal cortex passing through the posterior cingulate.
The authors additionally observed deactivations in the middle temporal gyrus, posterior cingulate cortex and contralateral anterior insula.
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