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In conclusion, this modelling study predicts that homodimerization of the TLR4 TIR domain creates a scaffold for the recruitment of adaptor molecules into a post receptor complex.
Second, only single biopsies were obtained in both studies, which may be insufficient because of the rapid and fluctuating nature of the post receptor signaling cascades.
While the responses of the early visual system (receptors in this case) may represent specifically the statistics of images, post receptor responses are more likely represent the statistical relationship between images and scenes.
In conclusion, the lack of change in the insulin receptor number in combination with multiple changes in post receptor signaling suggests a post receptor defect.
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Consistent with this, minimal stimulation of post-receptor signaling pathways was observed.
Therefore, another mechanism, probably an IGF-I post-receptor signaling defect, might be present.
Rod photoreceptor and post-receptor response amplitudes were significantly higher in VCM-treated than in vehicle-treated rats; deactivation of phototransduction was also significantly more rapid.
These functional assays indicated that the fish receptor can interact with its homologous ligand to evoke the downstream post-receptor events.
However, little is known about the post-receptor signaling events induced by EGF that lead to the transcriptional regulation of EGF-responsive genes in the ovary.
A study of signaling blocks involved in ACSM of relaxin in comparison with that of insulin previously detected showed a close similarity throughout the post-receptor signaling chain of both hormones.
Log kP2 was taken as a measure of post-receptor sensitivity.
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