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In this case, the dilemma was choosing either PKTx, with the possibility that this was an unnecessary therapy, or carrying out isolated kidney transplantation, risking a possibly unsuccessful transfer to sulfonylurea therapy and losing the advantages of double transplantation.
SWITCH is a well-designed trial in this therapeutic area that aims to develop a rational treatment algorithm to potentially inform personalised treatment regimens (as opposed to switching all patients to only one available (and possibly unsuccessful) therapy), which may lead to long-term improved patient outcomes and gains in population health.
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The existence of such a time period implies that invasion can possibly be unsuccessful if we take into account stochastic effects.
Efforts to secure an explanation from the White House were unsuccessful, possibly because many officials there were traveling with the president.
If it is unsuccessful, possibly because of a severe decline in the mortgage market, lots of employees will have to be laid off and the unions will complain.
Kennedy's efforts to "get the country moving again" have been unsuccessful, possibly because he has, despite the suggestions of many of his economic advisers, not yet advocated the one big step that might push the economy off dead center: a massive increase in government spending.
However, the procedure was unsuccessful possibly due to the effects of immunosuppression drugs.
Attempts at localization experiments using biotin labelled anti-TbMyo1 antibodies were unsuccessful, possibly because biotinylation affected recognition of the antigen.
However, many of the introductions seem to have been unsuccessful, possibly due to biotic interactions [47], [50].
Our attempt to confirm this result by WB was unsuccessful, possibly because the S100a8 levels were too low to be detected by WB analyses using this particular antibody.
Multiple 5' and 3' RACE mapping of these candidates was unsuccessful, possibly due to insufficient cDNA or because they are too small for satisfactory cloning.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com