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Reporters and IT technicians learned to work together, often for the first time, to prepare spreadsheets and searchable databases, simply to make it possible to interrogate the material and discover what it contained.
For the past 40 years, technological advances have made it possible to interrogate the entire genome; thus, the understanding of DNA modification has evolved significantly.
The field is likely to continue evolving as it becomes increasingly possible to interrogate larger tracks of DNA and decipher what genetic variations might mean for rare inherited disorders and common complex diseases alike.
It was shown that it is possible to interrogate and observe muscle behavior in real time, as well as selectively stimulate the contraction of myotubes with the device.
The availability of high-throughput target capture methods combined with the massive throughput of next-generation sequencing platforms has made it possible to interrogate thousands of genomic loci in a cost effective manner[5], [6].
Thus, it is possible to interrogate all 1024 unique pentamer binding sites with a single microarray.
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Given the lack of a research community and the sheer number of possible bacteria to interrogate, the development and application of technologies to rapidly and inexpensively advance these unstudied strains to 'model-organism' status is imperative.
The recent advances in molecular techniques and metagenomic studies based on 16S rRNA gene sequences have now made it possible to fully interrogate the resident mucosa associated bacterial communities.
As such, the skin is an excellent model system for these studies; it is accessible, it has a relevant environmental carcinogen (UVB), and it is possible to easily interrogate human disease.
However, with the advent of next-generation sequencing technologies, as well as the development of high-throughput genotyping platforms, it is now possible to simultaneously interrogate thousands of single nucleotide polymorphisms (SNP) from throughout the genome (Gupta et al. 2008), making possible the efficient development of increasingly dense genetic maps.
Since the NP film PNR fabrication process results in such a uniform population of PNRs, it is possible to simultaneously interrogate an ensemble of PNRs with a single optical measurement, as opposed to having to identify and characterize the rulers one-by-one, as is the case for immobilized NP dimer PNRs.
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