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It is possible that the disruption of auto-repression causes increased Myc levels at a time when these genes are sensitive to repression by Myc.
Since the expression of leptin [55], PGC-1α [56] and Nampt [57] is regulated by food intake, and the feeding rhythm is blunted in both AMPKα1−/− and AMPKα2−/− mice (Fig. 3C), it is possible that the disruption of the expression pattern of leptin, PGC-1α and Nampt mRNA may, at least in part, have resulted from feeding rhythm disruption.
It is also possible that the disruption of all five genes increases risk for SCZ.
It is possible that the disruption of the cytoskeleton was one of the causes of cell death induced by curcumin SDT.
It is possible that the disruption of initial NA formation decreases cell adhesion and leads to a decrease in cell speed due to a lack of the necessary traction for migration.
It is possible that the disruption of FA2H and ZNRF1 creates a deficiency in neural maintenance and repair, predisposing an individual to deleterious injuries that can result in neuropsychiatric disorders such as IED.
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It is possible that this disruption of glial architecture may partially contribute to the axon projection defects observed in Tsc1 mutants.
One possible explanation is that the disruption of ADE2 has a negative role on replicative lifespan.
It is possible that the social disruption of the Amin dictatorship and the following civil wars (1972 1986) favoured the spread of HPV, like other sexually transmitted diseases; HPV was found to be present in the great majority of cervix cancers in Uganda, with HPV type 16 in 53% (Bosch et al, 1995).
A possible mechanism is the disruption of intracellular signaling pathways that depend on Ca2+ homeostasis (Kodavanti 2005; Simon et al. 2007).
Another possible effect is the disruption of weather patterns outside the Arctic.
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