We cannot be certain that the people who are experts in the subject of medication error will find this exercise satisfactory, and it is for this reason that we include the first method above – it forms an insurance policy, as well as data for possible sensitivity analysis.
To achieve the highest possible sensitivity both samples were enriched for small RNAs with a cut-off range from 18 to 35 nt.
Gourtsoyianni et al. studied a group of patients with 15 solid malignant tumours (13 metastases, 2 HCCs) and 22 non-solid benign lesions (15 cysts, 7 haemangiomas) obtaining the highest possible sensitivity and specificity (100 %) for diagnosing malignancy [ 13].
The source temperature was 100°C, desolvation temperature was 400°C and desolvation gas of 600 L/h was applied, the remainder of the MS settings were optimised for the best possible sensitivity.
The Institute for Quality and Efficiency in Health Care (IQWiG) in Germany [ 23] and the Agency for Health Technology Assessment (AOTM) in Poland [ 14] explicitly mention that systematic searches need to aim for the highest possible sensitivity in order to ensure that no relevant studies are missed.
Testing for all known recessive mutations for individual loci is theoretically possible, and sensitivity for detection of carriers will improve over time.
The smaller SDs associated with USCOM convert to smaller 95% CIs and a possible increased sensitivity for detection of haemodynamic change.
By using lower carrier gas FRs than the one optimal for the sum of Fe and Mn intensities, it is possible improve sensitivities for refractory elements at the expense of other analytes, especially ones with high IPs.
Given the differences in preparation between both LBC methods, it is possible that the sensitivity for CIN II+ differs between them as well.
