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This was to ensure that possible sample size biases associated with studies of this nature do not occur.
An analysis would have been ideal to account for individual variability between groups and any co-linearity between variables, but would have produced a considerable loss in power as it would need to use the smallest possible sample size across task.
The population proportion has been assumed to be 0.50, as this magnitude yield the maximum possible sample size required.
Tissue requests should be for the smallest possible sample size, since the CHTN supplies those before considering large size requests.
If we accept an α level that is 'around' 10% and power 'around' 80%, then more than one possible sample size can arise (shown later).
It is thought that a maximum of 8% of participants randomised could have NMO, increasing the possible sample size to 50.
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The latter option makes it easier to calculate a range of possible sample sizes, as shown in the example above.
Repeat Steps 2 7 for all of the other possible sample sizes (5 173 for the laboratory sample, 5 151 for the AMT sample).
We provide SAS macro coding and an R function, which for a given treatment difference, allow researchers to examine all possible sample sizes for specified differences are provided.
Using BMI SDs as the primary outcome measure at 24 months of follow-up, table 4 shows possible sample sizes required for a definitive trial, for a number of possible scenarios (varying possible effect sizes and ICCs).
It can be difficult to choose from a wider set of possible sample sizes if software or tables only offer a solution where α is ⩽5% and power is ⩾80%.
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