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The report called for more research but effectively ruled out leukaemia as a battlefield hazard: the risk of this was about five in a million for all possible levels of exposure to radiation.
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Figure 2 illustrates the possible levels of detail in exposure information.
It is possible that different levels of exposure could affect the results; however, we observed ΣDAP concentrations (median = 81.3 nmol/L) comparable to the urban population in the Mount Sinai birth cohort in New York City (median = 75.9 nmol/L) (Wolff et al. 2007) and lower than those in the agricultural population of the CHAMACOS cohort (median = 136 nmol/L) (Eskenazi et al. 2004).
The second category of jobs (n = 9) represented a possible intermediate level of exposure, for example, retail jobs handling pesticides, crop-processing factory work, or working in an office adjacent to a farm or florist.
Population studies designed to examine possible mechanisms, patterns and levels of exposure, covariates and moderators of this relationship are warranted.
One possible mechanism is that at high levels of exposure, the DNA repair capacity is saturated even in individuals with a higher repair capacity [ 44, 45].
In the current study, we assess the possible impact of hypothetical interventions setting maximum levels of exposure to respirable elemental carbon in the DEMS ever-underground miners subcohort.
Nevertheless, data requirements may be well different, depending on the intended use and the possible sites of contact or the expected levels of exposure.
One possible reason is that at comparatively low levels of exposure, only some people are at risk, and this makes an association more difficult to find (Bellinger 2008).
However, whereas evidence appears to be consistent at high levels of exposure, risk at low levels and possible thresholds have not been well addressed.
It is also possible that lead may have different effects on thyroid hormones at different levels of exposure.
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