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A previous work identified some unavoidable issues in marine applications that imply uncertainty in knowledge of actual network nodes positions, and the resulting possible invalidation of the Extended Kalman Filter performance.
It faces four challenges: new technology, expiration of patents, possible invalidation of patent claims, and erosion of its proprietary database.
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In this paper, we apply our method of model invalidation to different possible and plausible connectivity structures in the chemotaxis pathway of R. sphaeroides.
Physicians should also be aware that the liability based on inappropriate use of a non-FDA-approved drug can be significant, and possible negative consequences can include the invalidation of their malpractice insurance, personal liability and possible criminal prosecution.
To evaluate the potential therapeutic effect of PTP1B invalidation, we used PTP1B-/ mice.
Applied in this way, model invalidation can be used to reduce the number of possible models [ 7], hence narrowing down the number of possible network connectivities.
It is also possible that the overall brain lack of response is due to the fact that the invalidation of the Prnp gene only affects a small subset of the brain cellular population and is therefore not detectable in our present transcriptomic analysis or in the proteomic experiment of Crecelius et al. [ 29].
It is shown that this approach yields an affine expression of the uncertainty model in all possible transfer functions that can be measured via a closed-loop experiments, which facilitates the optimization involved with a model invalidation.
So you are trapped in a cycle of invalidation.
Technically, the biggest challenge will likely be cache invalidation.
Something about court-appointed attorneys and the invalidation of wills composed while incompetent.
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