In addition, given that the impact of mitochondrial dysfunction may be more pronounced in metabolically active skeletal muscle tissue we further explored a possible intermediate phenotype, grip strength, in order to gain insight into the potential paths linking mtDNA to the frailty phenotype.
Using the coefficients of the multivariate regression (second to last column of Table 2) now makes it possible to predict grip strength by using an equation: For example, a 47-year old man 171 cm in height, weighing 72 kg and doing light work has an average grip strength of 50.3 kg in his dominant hand.
We chose a group with healthy volunteers, a homogenous group of patients with injuries (patients shortly after treatment of a distal radius fracture with a plaster) and a non-homogeneous group with various hand and wrist conditions to gain as much information as possible about the correlation between grip strength, grip strength ratio and DASH score.
To encourage the subjects to get a score as high as possible, the best of the six grip strength measurements was recorded and later used in statistical analyses, as recently recommended by Roberts [ 15].
Possible anchors include objective measurements, such as prehensile grip strength and ROM, or patient-reported anchor questions.
Subjects were instructed to sustain maximal grip effort as long as possible, and fatigue resistance was expressed as the time during which grip strength dropped to 50% of its maximum.
In the current study, higher UA levels were associated with poor grip strength and leg extension power by the following possible mechanisms.
Especially since Wang et al. (2006) found grip strength particularly predictive of dementia among those with mild cognitive impairment, it is possible that grip strength represents a marker during the preclinical course of dementia rather than a change that occurs prior to the processes associated with the development of dementia.
It is not our intention to replace DASH with grip strength ratio but to use grip strength ratio when the use of a PROM is not possible or suitable.
Grip strength and sensation were intact.
