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In patients with renal cell carcinoma, several doses of temsirolimus have been tested in clinical trials but toxicity leads to refrainment from using the highest possible dosing.
We have analyzed pharmacokinetic data for glycerol phenylbutyrate (also GT4P or HPN-100) and sodium phenylbutyrate with respect to possible dosing biomarkers in patients with urea cycle disorders (UCD).
Interviews generated two examples of possible dosing frequency errors: a once-weekly drug prescribed once a day, and drugs for Parkinson's disease.
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"Then, if they're used, to pay careful attention to using the lowest possible dose".
He and others suggest that women taking it to relieve severe menopausal symptoms should use the lowest possible dose and taper off as soon as possible.
She asks women who find their symptoms of menopause unbearable to try the lowest possible dose of hormone therapy, which may not rid them of their symptoms.
Doctors can minimize the damage by using only the lowest possible doses of radiation, said Dr. Anna T. Meadows, a pediatric oncologist at Children's Hospital of Philadelphia.
She said that women who want treatment should take the lowest possible dose that eases their symptoms.
In case of irradiation of medulloblastoma in Ashya, it is necessary to apply the highest possible dose into the former location but protect the tissue around as much as possible.
For cancer patients, the label calls for using the lowest possible dose that allows a patient to avoid blood transfusions, with hemoglobin levels not to exceed 12 grams for each deciliter.
The drugs, which contain cancer warnings on the label, are still approved to treat severe symptoms of menopause, but their use is advised at only the lowest possible doses.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com