A proposed direct interaction between Asp6336.44 and Asn6747.49, based on mutations experiments [38], is not observed in the structure of the model of the inactive TSHR TMD; however, a water-mediated hydrogen bond is possible (distance of 4.6 Å).
For example, the PDF distribution of the source-to-site distance measured from Chiang Mai province to the Ma Tha Fault Zone had the shortest possible distance of around 26.3 km and a probability of 0.99, whereas the longest possible distance was 113.8 km with a probability of <0.0003.
This either forbids sample points below a certain distance or selects a replicate at the maximum possible distance of the first replicate.
The RF distance between our supertree (Additional file 4: Figure S1) and this strict consensus tree was 31 out of a maximum possible distance of 298 for 152 species, also indicating concordance of topologies.
The values for the non-normalized weighting function are obtained by the maximum of possible distances to points of the contour line with a specified angle: (12).
Network radius is assumed to be r n=0.5×(2×r tr+r csr) which covers maximum possible distance for a valid placement of the nodes such that the resulting flows are interfering.
For shorter length sequences, the number of possible distances is also reduced.
For the moment, however, we shall treat Ro as a free parameter that ranges from a few light-years up to the maximum possible distance RM of an emitter from the Earth.
The key to the algorithm is to limit the number of calculated pairwise distances to a carefully chosen subset of all possible distances.
