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However, there has been a growing concern over the possible damaging effect of this surgery on ovarian reserve.
But I hope that editors moving to open review have put in a little time writing for Wikipedia and are aware of the possible damaging effect of highly motivated, unsupervised reviewers with time on their hands.
This variant is very rare in the general population (MAF = 0.1% in all 1000 Genome Project phase 3 individuals, 0.2% in 60,706 individuals of the Exome Aggregation Consortium ExAC), and has a possible damaging effect based on bioinformatic tools; the CADD PHRED-scaled C score is > 20, thus ranking in the top 1% of predicted deleteriousness of all possible single nucleotide variants [23].
PolyPhen and PolyPhen-2 predicted 1,479 and 672 SNPs as functional with probable or possible damaging effect on protein, respectively.
The causal polymorphism can be the rs17266594 SNP itself, which seems to alter splicing efficiency of BANK1, or two BANK1 nonsynonymous SNPs of possible damaging effect.
Therefore, it is clearly plausible that GLP-1, on the one hand, can help during a meal (glucose homeostasis, appetite control, fat metabolism), and on the other, can protect the endothelium against the possible damaging effect of the meal.
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In bridge widening projects, the possible damaging effects of traffic vibration on curing concrete stitch have been causing concern, and design engineers have to consider what traffic restrictions or mitigation measures are necessary.
However, possible damaging effects of excessive heat generated during polymerization have been warned[9 11].
Lentijo said that TEPCO should weigh the possible damaging effects of discharging toxic water against the total risks involved in the overall decommissioning work process.
We deem it important to perform molecular studies on radiation-induced changes in the thyroid at different temporal end points in order to gain a more in-depth understanding of possible damaging effects.
Notwithstanding a multitude of other potentially contributing factors to the various injuries outlined, addressing the possible damaging effects of excessive high-intensity training and/or poor diet is an important consideration.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com