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Many possible control interventions were considered and rejected for a variety of reasons.
Qualitative methods (interviews, focus groups and teleconferences) were used to explore trial feasibility with therapists and service managers from teams implementing both DDP and possible control interventions.
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We were able to examine several potential confounders, not always possible when analysing infection control interventions.
Additionally, this study had the ability to examine data on potential confounders, not always possible when analysing infection control interventions.
This makes it possible to focus infection control interventions.
A shift of susceptibility to severe malaria toward older children is theoretically possible in areas where malaria control interventions are being rapidly scaled up and has been reported elsewhere (5 ).
The prevalence of multiply resistant organisms (MROs) reported from south-eastern Mediterranean hospitals highlights the need to identify possible contributory factors to help design control interventions.
This information is then used in participative processes to identify job-specific causes and possible solutions, and to prioritise risk control interventions.
Because a RCT is performed to address uncertainty about comparator interventions, the choice of control intervention should adequately reflect, to the extent possible, "current standard medical practice".
A possible limitation in our study is the limited contrast in the content of the experimental and control intervention.
The control intervention was usual care.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com