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The automatic selection of references makes it useful to perform bulk analysis of many GEO or ArrayExpress experiments without the need of developing a parser to find the normal samples or possible batches within the data.
Lastly, whenever possible, batches of samples collected during the first visits of the patients, when changes in biomarker levels in response to drug treatment could be theoretically detected, should be assayed together in the same run.
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That is the information of possible batch arrivals is indeed included in the generator matrix of the driving process.
This study introduces a new generation of catalysts for possible batch esterification reaction using P-DES followed by an alkaline transesterification reaction.
Gene expression levels were not adjusted for possible batch effects as algorithms that attempt to adjust for batch effects also alter the gene expression distribution.
The 120 samples were blinded as to exposure status and split into two equal groups with a similar distribution in exposure status thus preventing possible batch effects.
The second step was to design gSG6-based peptides with the objective of optimizing and increasing Anopheles specificity and reproducibility of the assay, and overcoming limits in production of the recombinant protein and possible batch-to-batch variations.
Batch numbers were retained in order to adjust for possible batch-specific effects.
It also finds an optimal weighting of the samples minimizing possible batch effects.
Our LHS method is sensitive to possible batch effect and genotyping errors.
These data were analyzed separately within each study to avoid possible batch effects.
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CEO of Professional Science Editing for Scientists @ prosciediting.com