Having a digital copy of a person's metabolism in the cloud opens up many possibilities to interrogate that data not just for fitness but for overall health.
Many experimental models have been designed to interrogate the possibility of transgenerational epigenetic inheritance and provide insight into how environmental exposures influence phenotypes over multiple generations in the absence of any apparent genetic mutation.
To interrogate this possibility, we examined the sensitivity of pStat3 gradients to the changes in expression of gp130-Jak-Stat pathway components in silico.
To interrogate this possibility, we conducted gene expression profiling with total RNA isolated from the normal and cancer cell lines.
To interrogate the possibility of pathway 2, we alternatively combined DEA with Cu OAc 2 in the presence of K3PO4 in DMF at 100 °C (Scheme 4).
To interrogate this possibility, we performed propidium iodide (PI) DNA staining of cells and performed flow cytometry at time points after Wee1 siRNA treatment.
PARP has been shown to be important for MMEJ in mammalian cells [ 9, 10] and therefore a highly specific PARP1/2 inhibitor, KU-54936 (PARPi) could be used to interrogate the possibility that MMEJ is important in hESCs [ 9, 10, 32].
Hence, in that study, we have used mathematical modeling to interrogate these possibilities.
For high sequence similarity, each allele has a high possibility of binding to the probe which is designed to interrogate the other allele.
Recent studies have raised the intriguing possibility that the adhesive and de-adhesive dynamics between cells and the ECM may be used to interrogate cellular mechanics.
