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The fusion of the two proteins in B. pumilus raises the possibility that the function and transcriptional regulation of this alkyltransferase may be different in B. pumilus compared to B. subtilis and B. licheniformis.
Nevertheless, the possibility that the function of class II TXNs members is independent of their redox activity cannot be excluded in a similar way to what has been previously described to a eukaryote thioredoxin [44].
While murine BRIGHT protein seems to be prevalently found in the B cell-lineage, human DRIL1 expression appears to be ubiquitous, raising the possibility that the function of DRIL1 depends on the species and the cellular context [9].
Although it remains to be seen whether Cobra1 could regulate other putative targets in a similar fashion, our finding raises an intriguing possibility that the function of NELF may not be limited to modulation of transcription elongation.
In fact, the amount of AmMESK2-transcript was 1.5-fold higher in the forager brains than in the nurse bee brains, raising the possibility that the function of AmMEKS2 is more necessary in the forager brain than in the nurse bee brain (Supporting Information S1, Fig. S11).
This is particularly relevant if the function is shared by Archaea and Bacteria – it is necessary to argue that the sequence is homologous in the two domains in order to exclude the possibility that the function evolved independently.
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Although the biological impact of Zfp277-deficiency awaits detailed analyses of Zfp277−/− mice, the fact that these mice are born healthy raises the possibility that the functions of Zfp277 can be compensated for by other family members in vivo.
This raises the possibility that the functions of bHLH genes in neural subtype specification may largely represent vertebrate innovations.
This last interaction was particularly unexpected as yeaZ is not conserved in H. pylori, and suggests the possibility that the functions of yeaZ may be performed by another protein in this species.
This latter observation contrasts with results of similar experiments performed in Nanog null embryos (Messerschmidt and Kemler, 2010) and highlights the possibility that the functions of these two 'pluripotency' factors in the developing epiblast are different, despite the fact that Oct4 and Nanog frequently operate in partnership to activate target genes (Boyer et al., 2005).
The slowed relaxation rates in both Brody patients and nBmp2NLStm mice suggest the possibility that nBMP2 may function in some aspect of the SERCA1 production/activation pathway.
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