Nevertheless, our application of AICC, may correctly adjust AIC values for small sample size bias, but should not be interpreted to completely preclude the possibility of our large model overfitting a relatively small dataset.
Such possibilities should be investigated in terms of our model, which makes predictions that can be tested with integrated paleontological, geochemical, and sedimentological data.
An important point to be addressed in future analyses concerns the possibility of generalizing our models to new, independent datasets and, eventually, their application in clinical trials of experimental drugs intended for secondary prevention of dementia due to AD.
A two-point difference is within the realm of possibility, although our model would require a bit more evidence to support a difference that large (specifically, poor polling for Mr. Obama in non-battleground states relative to his polling in swing states).
The ability of a phagocyte to engage a preapoptotic cell is a required step for full execution of apoptosis; a possibility in our model is that impaired engulfment lengthens the survival of cells destined to die.
But at present no means exist of testing this possibility in our model, because there is no known appropriate surface marker of the CD4+FoxP3+ cells that might allow their selection and separation.
For a final answer the Pcnt spliceome in human tissues has to be deciphered a task that exceeds the possibilities of our group focusing on animal models.
In addition, we admit the possibility of multiple adducts in our model and must therefore keep track of which particular adduct a particular measured peak is assigned to.
A real study case illustrates an exploitation possibility of this model.
