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The generally well-conserved exon structure in HD-Zip III genes across different species highlights the possibility of conserved gene function and strict regulation of these genes.
For example, a subset of the ncRNAs detected in mouse in our study were also detected in rat tissues, suggesting the possibility of conserved functions restricted to the rodent lineage.
The study by Orjuela-Sanchéz et al. [ 3] hints at the possibility of conserved recombination hotspots within P. vivax; such hotspots, as they note, have also been observed in Plasmodium falciparum [ 8].
Similar negative effects of media acidification are also observed on chronological senescence of mammalian cell cultures due to lactate accumulation, which can be attenuated by TOR inhibition [ 13- 15], and raising the possibility of conserved aging associated pathways that are triggered by this type of stress.
In addition to common structural ancestory, the possibility of conserved function as modifiers of polyphosphoinositide-based cell signaling is also suggested.
Later bioinformatic analyses by Koonin and colleagues also suggested the possibility of conserved sequences common to E Pc) and Lin-49 during their seminal work on domain accretion [ 14, 15].
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Thus, its comparison with T. brucei provides the possibility of detecting conserved ncRNAs involved in or processed by this machinery.
For example, the possibility of breast conserving treatment significantly depends on the relationship between the tumour-to-breast size.
Together these data raise the possibility that H3Y41ph also delineates a subset of conserved elements outside of genes, at least some of which are known functional STAT5 enhancers.
The variation in flowering time observed in lignin mutants from S. bicolor and B. distachyon reinforces the possibility of an evolutionarily conserved mechanism between cell wall biosynthesis and production of flowers [ 60].
Given that the observed localization of harmonin in murine Müller cells differs from published work (Reiners et al., 2005), further investigation is needed, but our results are consistent with the possibility of a phylogenetically conserved role for harmonin in retinal glia.
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