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The possibility of clearance is assessed from limits on the specific activity of the material.
More than 30% of acute infections are asymptomatic with the possibility of clearance by the natural immune defenses while 70-85% of patients will develop chronic HCV infection [ 3, 4].
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Several host parameters, disease characteristics and virus-related factors are relevant to the possibility of viral clearance after therapy [ 6, 7].
Higher rates of treatment uptake among those under 15 years of age may reflect more frequent HCV RNA testing among this group not because they are on therapy, but as part of routine monitoring to better understand the natural history of infection in this patient group, where there may be a significant possibility of spontaneous clearance at any age in childhood.
A subsequent publication of Nedergaard's group reports the exciting possibility of an increased clearance rate of brain waste along the glymphatic pathway during sleep [ 163].
Another possibility of antibody mediated virus clearance is the activation of the complement cascade.
This array of possibilities is combined with the functional T-Map to compute a measure of all variational possibilities that will give each value of clearance.
However, in the afore-mentioned study, other mechanisms potentially impairing AB clearance were not investigated, leaving open the possibility of defects in other dead cell clearance effectors, such as phagocytes.
The possibility of a simplified Injected Activity clearance IA t) = IA0PT · exp−〈 λ 〉· t, 〈 λ〉 obtained fitting all sets of data together and the patient-specific IA0PT (IA at t = 0) was also investigated.
Further research should be undertaken to investigate the possibility of a genetic difference in the rate of clearance of ethanol (which could maintain the reduced hepatic redox state longer than expected).
Each trial utilized a flea-naïve cat host, minimizing the possibility of cat-derived, immune-mediated rickettsial clearance in feeding fleas.
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