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Since CHOP protein levels also peaked 5 h post-stimulation with DTT (Fig. 1D), the possibility of CHOP participating in the modulation of C/EBPα protein described above was considered.
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But I hate swapping bags – or I did until I started keeping stuff in little zipper bags, which makes switching that much easier and opens up all sorts of possibilities for chopping and changing.
Therefore, the role of CHOP as a pro-apoptotic protein is more convincing than other possibilities.
This raises the possibility that CHOP may be required for maintaining a high basal expression of Bim through a mechanism that does not affect Bim in conditions of increased ER stress.
Simon Wroe is the author of Chop Chop (Penguin).
Transfection of CHOP-targeting siRNA significantly attenuated the induction of CHOP after baicalein treatment.
R-CHOP is a combination regimen of CHOP with the anti-CD20 monoclonal antibody, rituximab.
For patients in advanced stages or in early stage with bulky disease, six to eight cycles of CHOP, R-CHOP or CHOP-based more aggressive regimen were given.
Using this model, we studied the effect of CHOP.
This study included 352 patients receiving 8 cycles of CHOP.
Increased protein levels correlated with induction of CHOP gene expression.
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CEO of Professional Science Editing for Scientists @ prosciediting.com