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Although we did not find differences in the expression of CTLA-4 or B7-H1 under conditions of hypoxia, we can't discount the possibility of alterations in the transcriptional activities of these receptors.
This result, although surprising, does not preclude the possibility of alterations specific to particular cellular regions.
One must also consider the time when such miRNA analysis was run and the possibility of alterations in the annotation of both miRNA sequence and chip design.
Long et al (2001) observed claudin-4 expression in metastatic prostate tissue samples; however, they failed to observe expression in the metastatic cell lines LNCaP and PC3, attributing this inconsistency to the possibility of alterations induced with long periods of passaging (Long et al, 2001).
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Furthermore, the possibility of alteration at the transcript level in high-risk families with no mutation identified through conventional testing should be considered (Knappskog et al, 2006).
Also, the possibility of alteration of the presence of other exogenous compound and the significance of this alteration in modifying drug interaction will only be determined by detailed pharmacokinetic studies that relate to the distribution of drugs metabolized by the microflora and their potentially active metabolites to the therapeutic response of the patient to the antibiotic.
Although there were no changes in NRF-1 expression observed in our chronic MPP+ setting, the possibility of functional alterations due to altered phosphorylation remains.
The possibility of the alterations in nasal morphology after the Le Fort I osteotomy is well documented in various publications [4, 7].
Instead, a clade comprising all demosponges except Homoscleromorpha is well-supported, and we define phylogenetically the name Demospongiae in this more restricted sense to preclude the possibility of drastic alterations of the meaning of Demospongiae in the future, depending on the position of Homoscleromorpha.
It was hypothesised that people recovered from AN would show some problems with emotional facial expression reflecting the possibility of trait alterations.
Given that BCCIP is involved in important processes relevant to the maintenance of genome stability and its localization at 10q26, we investigated the possibility of BCCIP alterations in more than 100 cases of astrocytomas.
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