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The lack of PKC involvement in the suppression of the sIAHP by PACAP inferred from the experiments where only PKC was inhibited does not entirely exclude the possibility of a function of PKC in the context of a crosstalk with the PKA/p38 MAPK pathway.
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All the tests were made in order to rule out the possibility of a functioning lesion.
Alternatively, we maybe seeing here something like a cannibalization of the social, a dismantling and destruction of the possibility of a functioning society, arranged and presented perhaps to edify the audience, perhaps to arouse it to respond, but certainly to entertain it meanwhile.
The direct interaction of PDE4D with the receptor, however, opens additional possibilities for a function of PDE4D in the β1AR complex.
However, no previous experiments have addressed the possibility of a circadian function for PDF released from the l- and s-Ab cells.
This raises the possibility of a separable function of Chd1 remodeling the yeast +1 nucleosome and ISWI-dependent transcription.
After showing a role for dCTCF in the maintenance of the maternal imprint, MacDonald et al. [ 5] explored the possibility of a similar function for this protein in the establishment of the imprinted state in the maternal germline.
Furthermore, similarities in the tissue-specific expression patterns between MOR-1 and MOR-1K, with lower abundance of MOR-1K relative to MOR-1 isoforms, support the possibility of a regulatory function for MOR1-K.
Recently, the possibility of an intracellular function of matricellular proteins was proposed, since (1) SPARC is located primarily intracellularly in non-pathological tissues, and is coincidently located with protein disulfide isomerase (PDI), a ER-resident protein, in pseudoachondroplasia chondrocytes [20], and (2) periostin appeared to be anchored in the Golgi [21].
The observed intracellular location supports the possibility of an intracellular function for AngII, in addition to the effects induced by activation of cell surface AT1 and AT2 receptors.
We [ 1] and others [ 5] have also observed nuclear and cytoplasmic expression within squamous and breast epithelial cells which raises the possibility of an additional function within epithelial cells.
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Justyna Jupowicz-Kozak
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