Development of such agents may identify compounds with improved efficacy, reduced side-effects and increased possibilities for modification.
This shows that the long binding site groove of Chit42 offers possibilities for modification of the enzyme toward, for example, pharmaceutically relevant oligosaccharides, e.g. COSs with defined acetylation patterns or substitutions at defined positions.
A combination of these two systems for RMCE has also been successfully tested in cell culture that expands the possibilities for modification of any single locus (Anderson et al. 2012).
Protein antigens present a quite promising alternative for vaccine development, due to the following characteristics: 1) absence of infectious materials like coding genes, 2) capability of inducing antigen-specific antibodies, 3) possibility for chemical modification and 4) the readiness for large scale manufacturing for a looming pandemic.
A crystal structure of the designed inhibitors demonstrates the ability of the P1 side pocket moiety to engage Lys192 and main chain of Gly216 via hydrogen bond interactions, thus, providing additional possibility for chemical modification to improve selectivity and/or physical properties of inhibitors.
Structure-guided drug design provides the possibility for rational modification and directed development of enhanced inhibitors.
Further, the maximum amplitude generated in the anisotropic coatings is greater than that for isotropic coatings, thus providing for a greater possibility of modification of the turbulence.
The possibilities for controlled modification of the phonon interactions and transport – referred to as phonon engineering or phononics – increased even further with the advent of graphene and two-dimensional van der Waals materials.
Ion beams offer unique possibilities for the modification of polymers: the highest known energy density, short range leaving the bulk properties unchanged and versatility in selection of areas to be treated.
We analyzed the criteria regarding potential deficiencies and considered possibilities for their modification.
