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One possibility for combination therapy with lapatinib is the small molecule inhibitor, OSU-03012.
As stated previously, one possibility for combination therapy with the FDA-approved drug lapatinib is the small molecule OSU-03012 as this novel Celecoxib derivative induces cell death in cancer cells from multiple lineages [ 11- 14].
Additional benefits, including the possibility for combination with insulin-dependent antihyperglycemic drugs, a low potential for hypoglycemia, and the ability to reduce blood pressure, were anticipated from the novel mechanism of action and have been demonstrated in clinical studies.
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This suggests, much as above, that there is a common mechanism of iron/hydroxyl-mediated cellular death underlying the action of all classes of bactericidal antibiotics and opens up many new possibilities for combination therapies based on promoting this kind of activity selectively (see Fig. 9).
We review the basic principles of these decomposition techniques and discuss for each promising possibilities for combinations with metaheuristics.
For high capacity electrode materials, this hybrid material strategy introduces possibilities for combinations of porous silicon carbide with other battery-type binary metal oxide materials.
New targeted agents mean new possibilities for combinations, a viable option to try to stop compensatory pathways of tumor growth activated in response to therapeutics.
Another paper showed the possibility for the combination of hormone ablation therapy and NSAID treatment [ 49].
Saccharomyces cerevisiae was chosen as the production host because of its relative tolerance to alcohols, robustness in industrial fermentations, and the possibility for future combination of isobutanol production with fermentation of lignocellulosic materials.
Because of the observed difference in survival between patients with colon or rectum tumours in single-marker analyses, we investigated this possibility for the combination of markers as well.
Plus symbols on the same row indicate where docking simulations support the possibility for this combination of adaptors to simultaneously bind to phosphorylated tyrosine residues on the same EGFR tail.
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