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We have unprecedented possibilities to phenotype our patients.
Thus, MICC opens a variety of possibilities to phenotype CTC and to correlate these results with the morphology of the cells.
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Open systems as MICC used in our study offer the possibility to phenotype CTC and compare the marker expression with the cell morphology.
One of the advantages of the presented model resides in the possibility to modulate phenotype severity by applying PT for different periods, allowing the study of physiological and biochemical implications of bilirubin toxicity at the desired developmental stage.
One of the advantages resides in the possibility to modulate phenotype severity by applying PT for different periods, allowing the study of physiological and biochemical implications of bilirubin toxicity at the desired developmental stage.
According to the consensus document on the assessment of plants derived from modern biotechnology, a molecular characterization must be included to provide assessors with the possibility to predict phenotypes and risk/safety concerns [ 1].
The possibilities to favor a certain cell phenotype and induce production of extra cellular matrix (ECM) were studied by histology, immunohistochemistry, and quantitative real-time PCR.
In vivo inhibitors should offer possibility to mimic the phenotype of plant ANTR1 mutants.
In the present study, we have focused on the role of the IGF/insulin axis on cell migration and on the possibility to suppress this phenotype using NVP-AEW541, a selective IGF-1R inhibitor (García-Echeverría et al, 2004), in MDA-231 cells, a human breast cancer cell line derived from a mTNBC.
The methodologies for association described herein can be applied to other data types, opening up possibilities to analyze transcriptome phenotype associations, and correlate microbial population structure or activity, as measured by metagenomics, to environmental parameters.
We have been investigating how interruption of differentiation contributes to the oncogenic process and the possibility to reverse the transformed phenotype by restoring differentiation.
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