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This opens up new possibilities for functional hypothesis-driven research.
JA-OCT also offers new possibilities for functional imaging such as angle-resolved Doppler OCT.
Gene silencing in the retina using RNA interference could open broad possibilities for functional studies of genes in vivo and for therapeutic interventions in eye disorders.
Together these results highlight the DARPin technology as an efficient platform to generate specific protein binders which open up new possibilities for functional analyses of fluorescent proteins in different cellular and developmental systems.
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Curators are particularly sensitive to the possibility for functional gains or losses in one or both duplicates when there is a gene duplication event in a protein family.
Traditionally open surgical repair of a ruptured Achilles tendon has been the first choice of treatment due to low re-rupture rates and the possibility for functional post-operative splintage [ 1- 4].
In another perspective, there is a possibility for functional redundancy between HDA5 and HDA18, since HDA18 is basically a duplication of HDA5 and share 84% homology mostly in the conserved HDA domain [ 1].
Consistent with the possibility for functional interaction, a recent study revealed time-dependent up-regulation of transcription factor-specific gene modules in an in vitro model of acute MYC activation [ 50].
However, the biology of LOH does not support this assumption and with large-scale tumour studies it is now possible to explore the many possibilities for the functional significance of this genetic event as summarised in Table 3.
The combination of ultrafine Pt NPs and mechanically tough NC gel may open up new possibilities for designing functional Pt-gel materials.
Here, we discuss the challenges of assigning mutation functionality and, drawing from the examples of ciliopathies as well as cohesinopathies and channelopathies, discuss possibilities for the functional modularization of the human genome.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com