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This demonstrated that all strains possessed defects in glucose sensing and/or metabolism after germination.
Another three mutants (Δ pph-4, Δ cdc-14, and Δ pph-8) possessed defects in the timing or in the number of ascospores produced.
We were interested to find that all three CRL (Class V) mutants possessed defects in both asexual and sexual development (Table 1).
To further support the hypothesis that the seven NPP mutants possessed defects in the ability to convert α-ketoglutarate to succinyl-CoA, α-KGDH activity was measured.
Collectively, these results demonstrate that the seven NPP mutants possessed defects involved in the detection of glucose and in the initiation of events essential for germination.
This suggested that these NPP mutants possessed defects in carbon sensing and/or metabolism, mechanisms that were essential for germination, in addition to post-germination defects in carbon metabolism.
Similar(53)
Attention then focuses on doubly periodic rectangular arrays of pinned points possessing defects.
Interestingly, the ΔptcD and ΔpsrA mutants also showed substantially reduced swelling and may also possess defects in glucose sensing.
As cancer cells possess defects in these pathways that provide an opportunity to target this organelle for therapeutic purposes.
This contrasts with knockout mutants lacking csp-1 or csp-2, which have reduced hyphal growth but do not possess defects in female sexual development (Broad database).
Our results demonstrated that Δ pty-5 mutants possess defects in conidiation, whereas strains lacking pty-6 are resistant to fludioxonil.
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