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About one-half of the anti-CCP+ RA possessed circulating ICs containing fibrinogen (p = 0.0004).
We demonstrated that one-half of anti-CCP+ RA patients possessed circulating (blood) ICs containing citrullinated fibrinogen, and that fibrinogen, immunoglobulin and complement component C3 co-localize in pannus tissue derived from RA patients.
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Most anti-CCP RA patients did not possess circulating ICs.
PsA and healthy control patients did not possess circulating ICs (PsA and healthy, green line).
The subset of juvenile RA patients possessing circulating ICs containing fibrinogen also possessed anti-citrullinated fibrinogen antibodies, RF and anti-CCP antibodies (Table 2).
This finding emphasizes the benefit of possessing circulating CD8+ anti-TAA cells and implicates CD4+ T cells as potential suppressors of such responses (for example as CD4+ Tregs).
We further demonstrate that approximately 50% of CCP+ RA patients possess circulating immune complexes containing citrullinated fibrinogen, and that citrullinated fibrinogen containing immune complexes are deposited in human RA synovial tissues.
Using a wide range of adipokines our current study showed that women possessed higher circulating levels of leptin, PAI-1 and adiponectin.
The finding that medicated obese women with schizophrenia have been shown to possess higher circulating β-endorphin levels than matched controls provides partial support for this hypothesis [ 30].
Recently, astronomers announced that data collected on the centaur Chiron as it passed in front of a bright star in 2011 suggest that it may possess a circulating disk of debris -- albeit invisible to Earthlings.
In addition, patients with rheumatoid arthritis had been reported to possess reduced circulating level of vitamin B6 and their plasma pyridoxal 5′-phosphate levels correlated with both the net Hcy increase in response to a methionine load test and 24 hr urinary XA excretion in response to a tryptophan load test [ 11].
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