Clusters that generated an HSP-bit score below 70 and or E values higher than 10-7 were assessed manually for all possible alignments taking into account the alignment length, number of identical matches, gaps, and positive replacements.
Even if Δ H is positive, the replacement occurs at a given probability.
At the same time, he has grown interested in what he sees as the pernicious influence of religion; while not as fanatical on the subject as Dawkins, he has at-tempted to launch "bright" as a more positive-sounding replacement for "atheist".
In antibody-positive patients, replacement of heparin by danaparoid sodium allowed the restoration of CVVH duration and efficiency.
Finally, although the diagnosis of HIT was not certain for all anti-PF4/heparin antibody-positive patients, replacement of UFH by danaparoid sodium allowed the restoration of CVVH duration and efficiency, supporting the clinical relevance of anti-PF4/heparin antibody assay in the case of repeated hemofiltration-filter clotting, at least in a surgical ICU patient population.
By contrast, under positive selection, rapid replacement of an amino acid is advantageous to the organism; hence, nonsynonymous mutations are fixed at a rate higher than that of neutral synonymous ones [81], [82].
In this view, substitution of Gly717 to Arg prevents the diphthamide biosynthesis but at the same time provides a "replacement" positive charge in this region which is sufficient to confer some degree of functionality.
For the Lux reporter we used a luxABCDE operon that had been previously modified for expression in Gram positive bacteria by replacement of the ribosome binding sites and reorganisation of the genes [41].
Upon transformation, seven colonies were screened by PCR and all the colonies were found to be positive for CORE6 replacement [Figure 3B (a)].
