At present, although the experimental data are positive and the rationale for use of hypertonic solutions in the care of patients with sepsis or septic shock is reasonable, definitive clinical studies as to the safety and efficacy in this patient population are still required.
For instance, Johnson and Johnson's framework that defines the necessary elements for successfully supporting cooperative or collaborative learning (e.g., individual accountability, positive interdependence) provides the rationale for design elements to help learners develop these skills.
Estrogen deprivation increased the apoptotic effects of PI3K and dual PI3K/mTOR inhibitors in ER-positive disease, providing a rationale for PI3K/aromatase inhibitor combinations as first-line therapy.
Recently, belimumab, an antagonist of B lymphocyte stimulator (BLyS), has shown clinical efficacy in the treatment of active autoantibody-positive SLE, providing a rationale for further investigating B cell targeted therapeutics (6).
"While some of these gains reflect government schemes, the rationale for the positive narrative is a much broader one, reflecting such factors as the improving economy and jobs market, consumer confidence and competitive mortgage deals," said CML chief economist Bob Pannell.
Spehar is very bullish on life insurance stocks for the near future and offered his rationale for the positive outlook.
Although it is not mentioned, the glimpse into small town America that American Honor Killings presents is a strong rationale for gay positive role models, including ally groups and self-esteem activities in the educational system -- and the sooner the better.
The underlying rationale for the positive effect of hybridization relies on the fact that hybrids may exhibit, at the individual level, heterosis and/or, at the population level, high genetic variance for relevant phenotypic traits (e.g., Facon et al. 2008).
SRS, therefore, holds important information not only by demonstrating the presence of inflammation but, in positive patients, could also provide a rationale for the treatment of the disease with unlabelled somatostatin.
Under neutral evolution, the ratio of non-synonymous (replacement) to synonymous (silent) substitutions is expected to be constant within and between species, but the value will deviate if positive selection is operating, providing the rationale for the McDonald-Kreitman test [21].
