Sentence examples similar to positive damage from inspiring English sources

With the exception of one sample (mostly two apoptotic cells) we also did not detect up-regulation of p53 or the formation of p53BP1-positive damage foci thus excluding uncapped telomeres in the HSC populations including those from the oldest donors (figure 6).

Pre-existing chronic kidney disease (CKD) was determined as estimated GFR (eGFR) <60 ml/minute per 1.73 m or positive kidney damage markers, such as proteinuria (urinary protein of more than 30 mg/g creatinine or dipstick 1+ or more), urine sediment abnormalities and structural abnormalities detected by imaging, or both, according to the KDIGO CKD guideline [ 24].

Although there are gaps in the database for dichloromethane genotoxicity (i.e., DNA adduct formation and gene mutations in target tissues in vivo), the positive DNA damage assays correlated with tissue and/or species availability of functional glutathione S-transferase (GST) metabolic activity, the key activation pathway for dichloromethane-induced cancer.

TUNEL-positive DNA damage, which depends on caspase activity in other cells, is caspase-independent in ischemic cardiomyocytes and ischemia-induced DNA high and low molecular weight fragmentation is blocked by repressing EndoG expression.

Our results suggest that ischemia-induced TUNEL-positive DNA damage in cardiomyocytes in vitro is triggered by EndoG and depends on EndoG release from mitochondria induced by Bnip3 in a way that can be partially blocked by Bcl-xL, without the involvement of caspases.

This finding demonstrates that not all pyknotic profiles represent cells undergoing apoptosis that depends on caspase-3 activation and that apoptosis determined by TUNEL-positive DNA damage can occur irrespective of caspase-3 activation in some circumstances such as hypoxia [48].

A cell containing more than 10 γ-H2AX foci was considered to be positive for damages to DNA.

These authors suggested there were other cortical and medullary stem-cell populations within the tubules that assisted kidney repair and that were also Ki67-positive after damage.

Propidium iodide-positive cells (damaged plasma membrane) showed a red-stained nucleus, FITC-PSA-positive cells (damaged acrosome) presented a yellow-green acrosome region, JC-1 -positive cells (high mitochondrial potential) showed a bright red-orange colour in the mid-piece region, and JC-1-negative cells (low mitochondrial potential) presented a bright green colour in the mid-piece region.

The glutathione peroxidase gene has positive function to damage induced by ROS.

The activation of caspase-9 was also observed in neurons positive for oxidative damage to DNA/RNA.