Although these tests have become the benchmarks for defining tumors as HER2-positive, considerable controversy still exists regarding the accuracy, reliability, and inter-observer variability of these assay methods.
So, COSMIC data can make a positive and considerable impact on global ionosphere studies providing essential information about vertical distribution of the electron density and particularly over regions that are not accessible with ground-based instruments such as ionosondes and dual frequency GPS stations.
The full economic costs have yet to be evaluated, but there is little doubt that the implications of these studies have been both positive and considerable for health care provision in Indonesia.
If postscreening analysis requires resynthesis of the hits, then these false positives consume considerable time and resources.
While false positives receive considerable and certainly well-deserved attention in the context of acoustic surveys (e.g. Marques et al., 2009, 2012; McClintock et al., 2010), the same problem potentially occurs in visual surveys and is often ignored.
But local authorities have a considerable positive track record of innovation and change.
One of his children, a bearded iris named Muses's Visit, has brought him considerable positive attention among his fellow iris fanciers.
As its architects, we are extremely proud of the considerable positive impact which the academy has had on the lives of the local community.
Starting with her association with the Vera Institute of Justice in the mid-1960s, she developed a passion, a base of knowledge, and a group of like-minded friends and colleagues that allowed her to effect considerable positive change for the incarcerated in New York City.
There are no simple answers, but one thing is certain; neither voters nor consumers will support sustainability as a priority unless it offers considerable positive impacts on their everyday lives.
Nearly all Australians learn to swim early and those who excel receive considerable positive reinforcement from a society where the best swimmers are in the spotlight every year, not just every four years.
