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In particular, free TUNEL positive thymocytes and TUNEL positive "aggregates" were observed.
Additionally, some cells contained HA positive aggregates with TUNEL negative (Figure S1, asterisk).
Interestingly, RNF5 inclusions partly co-localized with beta-amyloid positive aggregates (Fig. 1C) but not with phospho-tau containing structures (Fig. 1D).
Moreover, at least one third of these positive aggregates contained more than one copy of SIV DNA (with up to 20/20 PCR positive for SIV DNA, Table S2).
Importantly, TDP-43 function could also be affected without the presence of TDP-43 positive aggregates [ 13].
At Day 1, no GFP positive aggregates could be observed in the knee joint except the defects with a fluorescent stereomicroscope.
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Here, however, we have shown that D-ribose reacted quickly with α-Syn to promote aggregation of glycated products into ThT-positive aggregates (Fig. 9A).
While in P1-KO muscle fibers desmin-positive aggregates were restricted to perinuclear areas, in MCK-Cre/cKO cells, massive aggregation was observed all over the sarcoplasm (Fig. 2A).
The white arrows indicate the typical p62-positive aggregates formed by S228P-GFP.
These immunoreactive PrP-positive aggregates were PK resistant (data not shown).
The amyloid character of the ThT-positive aggregates was confirmed by electron microscopy.
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