Sentence examples for positive aberration from inspiring English sources

Note that we must compute the Poisson-binomial parameters for each position by considering the existence of the false positive aberration calls from normal samples.

As concordant false positive aberrations mimic polymorphisms which exist in both cancer and normal genomes, they appear recurrently at the same position and frequency in both the true and false positive aberration matrices.

We simulated aberration profile matrices; in each simulation, we obtain a pair of true and false positive aberration matrices.

Positive aberration calls were defined by ≥3 consecutive probes and overreaching 0.2-fold change of log2 space.

Here, we address the problem of how to test for the recurrence of genomic aberration in the presence of false positive aberration calls.

When the aberration profile matrix of unpaired normal samples from the same cohort is available, the Poisson-binomial approach enables us to test for the recurrence of aberration by denoising the false positive aberration calls.

The algorithm also allows for explicit control of the false discovery rate (FDR), which minimizes the number of false positive aberrations detected.

Concordant false positive aberrations.

Only concordant false positive aberrations exist in S. Concordant true aberrations.

To generate matrices, we assumed three types of aberrations: concordant true non-concordant true and concordant false positive aberrations.

These results demonstrate that PART-up can successfully discriminate concordant true aberrations from concordant false positive aberrations, suggesting its applicability to genomic data obtained in unpaired experimental designs.