Clones obtained replacing different residues at the same positions displayed strikingly different phenotypes, demonstrating that a precise choice of amino acid substitutions is fundamental to optimize immune-escaping, packaging ability, infectivity and tropism.
Multiple Africans have been placed to occupy executive positions (displaying a mirage of African ownership) but the real financial benefits are continuously rendered to outsiders.
"I was thinking a lot about neoclassical odalisques marble statues of female figures twisted in unnatural positions displayed at the Metropolitan Museum of Art or in the Louvre," Torn tells The Creators Project.
Although some signature positions displayed a clear separation among the three groups, some were less convincing, yet still notable.
The positions displaying disparity are likely the result of flexibility or "breathing" often observed in RNA structures and/or additional tertiary RNA-RNA interactions which occur and which are not detected using standard structure predictions.
However, all amino acid positions displayed in red interfered with the proper function of Taspase1.
Some of the intron positions displayed inter-species conservation which supported our predictions (data not shown).
In the 16,568 mtDNA nucleotide positions, 156 positions displayed a false deletion of greater than 0.15 in one or more individuals (Additional file 3, Table S3).
Unexpectedly, only mutations on the Arg248 and Arg282 positions displayed significant association with shorter patient survival, but such association was not evident for other hotspot GOF mutations.
Third codon positions displayed a high AT-content with similar values at both strands (AT = 81.30% on strand; 80% on strand), and a large variation across species.
