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Several properties of Activated Protein C, including its unique positioning to regulate coagulopathies in the microvasculature and the ability of EPCR to facilitate Protein C activation, support the continued development of Activated Protein C-mediated strategies that are aimed at disrupting the process whereby inflammation initiates coagulation and coagulation amplifies inflammation.
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As such, neurotrophins are positioned to regulate the availability of inflammatory cells derived from the marrow, through both direct[41] [44] and indirect mechanisms.
Thus, Rio2 is positioned to regulate the Nob1-dependent cleavage, but also, potentially, to be regulated by several of the key proteins in the final step of 40S maturation.
We show that the machinery for clathrin-mediated endocytosis is positioned to regulate the distribution of adhesion proteins in a subcellular region just proximal to the neuronal cell body.
These data are in support of electrophysiological evidence suggesting MR are functionally positioned to regulate synaptic excitability at synapses and, in turn, the acquisition of fear memories [5], [8], [17], [18], [30], [77].
Expression of the MRs at both the presynaptic terminal and the PSD suggest MRs may be positioned to regulate glutamate release from the presynaptic terminal and also to regulate post synaptic responses, both of which has been demonstrated by recent electrophysiological studies [10], [52].
To substantiate further our hypothesis that NGF is an immediate response gene potentially positioned to regulate the survival of bronchial epithelial cells during RSV infection, we timed the early-phase cellular response to the infection monitoring viral and NGF transcript levels by real-time PCR at hourly intervals for the first 6 h of incubation.
65 Astrocytes are well positioned to regulate synaptic transmission and the neurovascular network.
The forebrain hem system is therefore positioned to regulate the development of the telencephalon, and potentially also its expansion in evolution.
Since PIPKIγ_i5 is partially localized at several types of endosomal compartments, this splice variant is positioned to regulate the endosomal trafficking of N-cadherin, E-cadherin otherher proteins at multiple steps within the endosomal system.
"If we're not in the position to regulate the quality, we shouldn't be issuing new charters".
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