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Paraffin embedded pancreatic sections from 5 month old diabetic mice expressing HNF1A-MODY in beta cells also demonstrated elevated expression of PSP/reg throughout the islets compared with wild-type mice, with PSP/reg positive cells positioned in the vicinity of cells displaying apoptotic nuclear morphology.
Thus, positively charged amino acids such as lysine or arginine are frequently positioned in the vicinity of the N1 position of the isoalloxazine ring to stabilize the uptake of the negative charge in the flavin ring system.
Molecular modeling (docking) studies show that the methanesulfonyl (MeSO2) COX-2 pharmacophore present in regioisomers 13a,b is positioned in the vicinity of the COX-2 secondary pocket.
A molecular modeling study where (12d) was docked in the binding site of COX-2 showed that the MeSO2 COX-2 pharmacophore was positioned in the vicinity of the secondary COX-2 binding site near Val523.
When cholesterol was positioned in the vicinity of anandamide, Monte Carlo simulations indicated that both lipids progressively changed their conformation to find a remarkable complementary fit.
In these experiments, 0.5 mM choline was pressure-applied via picospritzer pipettes positioned in the vicinity of recorded CA1 pyramidal neurons or CA1 interneurons (Figure 1A B).
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Moreover, we have shown that a nuclear matrix attachment site (S/MAR), which is positioned in the immediate vicinity of the D4Z4 repeat array [14], may function as an insulator and block the D4Z4 enhancer in normal, but not FSHD, cells [13].
This indicates that the F' plasmid is positioned preferentially in the vicinity of these regions in fast growing cells, as expected given the preferred location of the F plasmid in mid, 1/4, and 3/4 positions in the cell, which are also preferred positions for Ori/ Ter regions during the cell cycle (Gordon et al., 1997; Niki and Hiraga, 1997).
This that the F plasmid is positioned preferentially in the vicinity of these regions in fast growing cells, as expected given the preferred location of the F plasmid in mid, 1/4 and 3/4 positions in the cell, which are also preferred positions for Ori/ Ter regions during the cell cycle (Gordon et al., 1997; Niki and Hiraga, 1997).
According to one possibility discussed in step 12, the active zone tethering machinery may even be involved in keeping the precursor vesicle in the synapse, and may therefore also position it in the vicinity of the membrane, favoring the subsequent fusion event between the two organelles.
The UN said another 81 peacekeepers were "currently being restricted to their positions" in the vicinity of Ruwaihaniyeh and Burayqa.
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