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Paraffin embedded pancreatic sections from 5 month old diabetic mice expressing HNF1A-MODY in beta cells also demonstrated elevated expression of PSP/reg throughout the islets compared with wild-type mice, with PSP/reg positive cells positioned in the vicinity of cells displaying apoptotic nuclear morphology.
Thus, positively charged amino acids such as lysine or arginine are frequently positioned in the vicinity of the N1 position of the isoalloxazine ring to stabilize the uptake of the negative charge in the flavin ring system.
Molecular modeling (docking) studies show that the methanesulfonyl (MeSO2) COX-2 pharmacophore present in regioisomers 13a,b is positioned in the vicinity of the COX-2 secondary pocket.
A molecular modeling study where (12d) was docked in the binding site of COX-2 showed that the MeSO2 COX-2 pharmacophore was positioned in the vicinity of the secondary COX-2 binding site near Val523.
When cholesterol was positioned in the vicinity of anandamide, Monte Carlo simulations indicated that both lipids progressively changed their conformation to find a remarkable complementary fit.
In these experiments, 0.5 mM choline was pressure-applied via picospritzer pipettes positioned in the vicinity of recorded CA1 pyramidal neurons or CA1 interneurons (Figure 1A B).
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Moreover, we have shown that a nuclear matrix attachment site (S/MAR), which is positioned in the immediate vicinity of the D4Z4 repeat array [14], may function as an insulator and block the D4Z4 enhancer in normal, but not FSHD, cells [13].
The biopsies revealed, that the GFAP-positive EGCs, which highly express GDNF, are positioned in the mucosal plexus in close vicinity to the mucosal epithelium.
Our study also presents erythroblasts penetrating between endothelial cells of the blood islands indicating their migration; they may be subsequently positioned in the subepicardium in the close vicinity to blood islands.
Analyzing the complex using radial distribution function (RDF) and a novel analytical tool termed the axial frequency distribution (AFD) illustrated that after simulation the ligand is positioned in close vicinity of the protein active site where Thr42 and Asp43 participate in hydrogen bonding and stabilization of the complex.
This that the F plasmid is positioned preferentially in the vicinity of these regions in fast growing cells, as expected given the preferred location of the F plasmid in mid, 1/4 and 3/4 positions in the cell, which are also preferred positions for Ori/ Ter regions during the cell cycle (Gordon et al., 1997; Niki and Hiraga, 1997).
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