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These known problems limit the spatial resolution and accuracy of the positional dataset obtained [19], [20].
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So that annotation information was consistent between all datasets, the positional information for all the genotype datasets was converted to build 36 of the Human genome using the UCSC liftover tool when necessary [ 41].
This condition is sufficient to ensure that, for our chosen imaging modality, our synchronization scheme is able to acquire a 3D dataset with positional resolution equivalent to that which would be achieved were the heart hypothetically to be "frozen in time" for scanned 3D imaging.
2) What consistent cis and trans-eQTL patterns emerge across datasets including positional genomic location and overlap with regulatory annotations?
Consolidate weak positions in positional play.
Neuronal projections were identified in a FIB/SEM dataset by this positional information and by the characteristic dense content of neurofilaments (Fig. 6B and data not shown).
Thus, from the dataset of 4052 positional candidates the method ranked 435 to be most likely disease candidates.
We examined the positional overlap of three such datasets.
To assess significance of positional biases, PEAKS uses random datasets to estimate a P value for each binding factor.
We have been able to identify a number of motifs that show positional bias in tissue-restricted datasets.
The distribution of values is presented on fig. 3. The distribution shows strong relative positional preference of the two datasets with maximum at around -80, i.e. spanion clusters are typically mapped to the 3' ends of the RNAPII segments.
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