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Three genomic regions on HSA21 were enriched with the significant genes using the MSigDB_c1 positional database: chr21q22, chr21q21 and chr21q11, located on the q-terminal arm.
New types of data, such as Simple Sequence Repeats (SSRs) on the genome, can be easily added to the Positional Database for visualization via SNUGB.
No significantly enriched gene sets were identified using the C1 (Positional) database in this study for MPRED or DEX, indicating that genes associated with GC resistance were not confined to particular genomic loci.
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Finally, gap positions are introduced to the candidate sequence so that the final alignment is the same length as the reference database and positional homology is maintained using the nearest alignment space termination (NAST) algorithm.
This is a routine maintenance that would be expected in any database holding positional information on a genome that is actively maintained.
The GO gene sets databases (C5.bp.v4.0, C5.cc.v4.0, C5.mf.v4.0) and positional gene sets (C1.all.v4.0) from the Molecular Signatures Database (www.broadinstitute.org/gsea/msigdb/index.jsp) were used for enrichment analysis.
Consolidate weak positions in positional play.
For each significant QTL, the 1.5 LOD support interval [ 29] depicted as a black bar on the x-axis of Figures 2, 3, 4 and 5, was searched for positional candidates in the NCBI database.
Analysis of the Inr positional distribution for the considered database (see Additional file 1, Supplemental Figure S3c) shows significant over-representation for the Inr motif in the area (-1 to +9 bp).
DIANA-microT[ 6], MiRanda[ 7], TargetScanS[ 5], and PicTar[ 4] are four genome-wide prediction algorithms whose results are available through miRGEN [ 8- 11], an integrated database of (i) positional relationships between animal miRNAs and genomic annotation sets, and (ii) animal miRNA targets according to combinations of widely used prediction programs.
Non-positional information, such as sequence database accession numbers and literature references, are viewed as a tooltip displayed when the mouse hovers over a sequence's ID.
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