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We generated analogous mutations at the corresponding residues in Ssc1: arginine at 103rd position, substituted to tryptophan (R103W); and proline at 486th position, replaced by serine (P486S).
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The profile-based searches against partial consensus sequences (only most informative positions replaced by consensus) were somewhat less efficient, especially when more false hits were allowed (Fig 2; MET-partial).
In doing so, we took into account that a position could occur in several correlated mutation pairs; such position was replaced by the same random position in all its correlated mutation position pairs.
At this time, the heavy firing from the enemy position abated, replaced by what sounded like hoots of braying laughter.
In a number of naturally occurring sugars, known as deoxy sugars, the hydroxyl group at a particular position is replaced by a hydrogen atom.
Alastair Cook's dream of leading England into the World Cup in February and March came to an end when the national selector, James Whitaker, informed him that he was being relieved of the position and replaced by his vice-captain, Eoin Morgan.
Further, one hydrogen atom of –NH2 group in 14 (R3) position was replaced by –SO2CH3 group.
Those rumors proved to be true on November 9 when Braun was forced out of the top position and replaced by iCasts COO Margaret Heffernan, the founder of ZineZone, another CMGI property.
Commanding officer Lieutenant-Colonel James Hill was wounded attacking an Italian position and replaced by his second in command, Alastair Pearson.
Multiple sequence alignment demonstrates some degree of conservation of this amino acid, especially among mammals, however, in some other species the isoleucine at this position is replaced by a valine (Table 5).
In some kinases in STE20 family, the threonine residue at this position is replaced by valine or cysteine.
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