Sentence examples for position of functionality from inspiring English sources

This suggests that the position of functionality within the scaffold and/or its conformation is crucial for the activities of the inhibitors reported here.

Extensive studies on RCM have been performed using chemically diverse substrates, outlining the influence in the macrocyclization of the presence and position of functionalities, the molecular constraints and the importance of the site of ring closure.

We prepared a simple pharmacophore plot identifying the optimal positioning of functionality crucial for binding to the Stat3-SH2 domain.

It is concluded from the present study that pKa value is not only ruled by the position of oximino functionality in the pyridinium ring, but also by the position of linker.

Variations in both the substitution pattern and the position of hydroxyl functionality allowed manipulation of p Ka values over a wide range, providing valuable information that can be used for future rational design of the indicator systems.

Position of the carboxylate functionality is critical to potency.

We suggest that it can be of interest to study the relationship between network position and functionality of proteins in the protein interaction network, even if our work indeed did not intend to predict causing-disease genes.

Changes in the intermediate filament network alter not only the intracellular distribution of AP3 but also the positioning and functionality of late endosomes and lysosomes demonstrating a strong link between intermediate filaments and the endocytic pathway [ 85].

We also showed that the position of sequence variants influence the functionality of the encoded protein.

A lidocaine test was given to determine the functionality and position of the catheter tip in the subarachnoid space.

Cezanne stresses the shape and position of the apples over their functionality and appeal as a source for nourishment.