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Thus, our findings suggest that ERMD functions to position division sites in proximity to nucleoids to increase the probability of their distribution upon mitochondrial division.
To further investigate the functional significance of these observations, we explored the idea that ERMD serves to position division sites adjacent to actively segregating mitochondrial nucleoids, which is based on the observation that ERMES is spatially linked to actively replicating mitochondrial nucleoids (Hobbs et al., 2001; Meeusen and Nunnari, 2003).
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We also provide evidence that ERMD positions division sites adjacent to mitochondrial nucleoids to bias their distribution into newly generated tips following division.
In summary, we propose that the asymmetrically positioned division machinery – the de novo-generated source of asymmetry – positions SpoIIE to be captured at the adjacent cell pole, triggering σF-directed gene expression in the forespore.
Therefore, positioning divisions apically in pseudostratified neuroepithelia could serve to safeguard epithelial integrity and enable proper proliferation and maturation.
Reconstructions of zebrafish early embryonic development by scanned light sheet microscopy provide a 'digital embryo' with a database of cell positions, divisions and migratory tracks [18].
This quantitative description of kinetoplast position during division is consistent with existing descriptions of basal body movement during the cell cycle [ 18] and division of the kinetoplast [ 44].
A spokeswoman for the ABC said: "ABC News has been considering a range of ideas to identify savings, find more efficient ways of operating and best position the division for the future.
Jean Tigana's men secured their third victory in three games with a finely tuned, stylish performance dominated by slick passing, movement, goals and controversial incidents as they confirmed their position as division leaders.
Michael was in a fairly unique position in Division, having trained so many of the recruits.
Following three successive top-eight finishes, the 1949 50 season ended with Ipswich in 17th position in Division Three (South), the club's lowest ever league finish.
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