But every concept of strategy -- sustainable competitive advantage, positioning, differentiation, added value -- flows from purpose.
Wnt signalling helps to maintain an undifferentiated state of the intestinal stem cells [16], [17] and, paradoxically, also regulates positioning, differentiation and maturation of Paneth cells [13], [18].
Conversely, TGFβ/BMP signals predominate towards the open end of the crypt where they are thought to influence crypt cell positioning, differentiation and apoptosis.
In the traditional view, differentiation occurs upon exit from the Paneth cell zone, at the so-called "origin of differentiation" around position "= 5" where cells choose between the secretory and absorptive fates (Bjerknes & Cheng, 1981).
We next performed ChIP-sequencing in wild-type Flk1+ cells and progenitor cells to test which of the deregulated genes were direct targets of Sp1 and to examine whether Sp1 shifted position during differentiation and targeted different genes.
During development many genes, notably of the HOX family, determine cell identity, position and differentiation status by DNA methylation and these relationships may not be responsive to the local post-natal environment; further in vitro flow experiments will resolve such differences.
Correct positioning and differentiation of neurons during brain development is a key precondition for proper function.
Macy's is in dire need of a clear positioning or differentiation strategy, and those celebrities aren't it.
