Sentence examples for posing substantial challenges from inspiring English sources

A second challenge to the use of HRQOL instruments with young children, is that these should ideally be completed by the target population, posing substantial challenges in very young responders.

The parasite can infect diverse salmonid species with varying levels of severity (Hedrick et al. 1999), raising concerns over protection and management of native species and posing substantial challenges to commercial hatchery operations (House 2006).

Nonetheless, the uncertainty and variability of wind power pose substantial challenges for electric power system operation.

However, temporality of experience poses substantial challenges to traditional reductive evaluation approaches.

Changes in drivers, vehicles, and roadways pose substantial challenges to the transportation safety community.

Soft tailings pose substantial challenges for mine reclamation due to their high void ratios and low shear strengths, particularly for conventional terrestrial reclamation practices.

The diversity of HTS assays and screening results types pose substantial challenges as to the organisation and integration of the resulting data.

These dangers pose substantial challenges to humanity and nature, with a magnitude that is directly linked to the management practices we choose to retreat from further tipping points and irreversible changes from GHG emissions (Lenton et al. 2008, Solomon et al. 2009).

Among the large number of stressors temperature is considered a particularly important one, because variable thermal environments are common and may pose substantial challenges for individual survival and reproduction [4] [8].

Pragmatic trials on complex interventions in primary health care pose substantial challenges to investigators.

These multiple alignments pose substantial challenges to existing RNA-seq analysis tools.