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The linearity of eukaryotic chromosomes presents challenges to cells, as the presence of DNA "ends" poses problems for the DNA replication machinery and the cell's damage response systems.
This difficulty is thought to arise from the GC-rich nature of telomeric DNA, which gives it a high thermal stability and also allows it to form stable secondary structures, such as G-quadruplex DNA, which can pose problems for DNA replication (Lopes et al. 2011; Paeschke et al. 2011).
Concentrated wealth poses problems for both countries.
Such anonymity poses problems for taxmen.
Seawater poses problems for humans.
It poses problems for biometric ID systems.
The crisis in Korea poses problems for the media.
Male domination poses problems for women politicians.
That poses problems for Palm's contract manufacturer, Flextronics International.
Linear chromosomes pose a problem for replication of the terminal section of the DNA strand with a 5' end.
Inflation may pose problems for small businesses.
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